تفاعل #84514

معادلة التفاعل

(Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide

triethyl orthoacetate

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title compound

المردود 70.0%

3-(3-trifluoromethyl-4-morpholinophenyl)-2,6-dimethylpyrimidin-4(3H)-one

المردود 70.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was cooled to rt
2. 2
   تركيزconcentrated in vacuo
3. 3
   أخرىThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

الإجراء التجريبي

A mixture of (Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide (4.0 g, 12.1 mmol) and triethyl orthoacetate (10 mL) was stirred at 150° C. overnight. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a pale yellow solid (3.00 g, 70%). The compound was characterized by the following spectroscopic data:

المصدر