تفاعل #84442

معادلة التفاعل

4-(3-chloropropyl)morpholine

K2CO3

2-fluoro-4-nitroaniline

→

title compound

المردود 63.0%

2-fluoro-N-(3-morpholinopropyl)-4-nitroaniline

المردود 63.0%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   تركيزconcentrated in vacuo
3. 3
   أخرىThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

الإجراء التجريبي

To a suspension of 4-(3-chloropropyl)morpholine (1.64 g, 10 mmol) and K2CO3 (4.14 g, 30 mmol) in acetonitrile (20 mL) was added 2-fluoro-4-nitroaniline (1.56 g, 10 mmol) dropwise. The mixture was stirred at rt for 24 h, then filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as yellow oil (1.78 g, 63%).

المصدر