تفاعل #84406

معادلة التفاعل

1,2-difluoro-4-nitrobenzene

K2CO3

pyrrole

→

title compound

المردود 97.0%

1-(2-fluoro-4-nitrophenyl)-1H-pyrrole

المردود 97.0%

المذيبات

DMSO

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled to rt
2. 2
   ترشيحfiltered
3. 3
   أخرىthe filter cake was dried

الإجراء التجريبي

To a solution of 1,2-difluoro-4-nitrobenzene (1.59 g, 10 mmol) in DMSO (15 mL) were added K2CO3 (3.04 g, 22 mmol) and pyrrole (0.74 g, 11 mmol) with stirring. The reaction mixture was heated at 90° C. for 18 h, and cooled to rt. The mixture was diluted with water (50 mL), filtered and the filter cake was dried to give the title compound as a yellow solid (2.00 g, 97%).

المصدر