تفاعل #84404

معادلة التفاعل

tert-butyl (2-fluoro-5-morpholinophenyl)carbamate

HCl

→

title compound

المردود 57.0%

2-fluoro-5-morpholinoaniline

المردود 57.0%

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water (150 mL)
3. 3
   استخلاصextracted with CH2Cl2 (100 mL×3)
4. 4
   غسيلThe combined organic phases were washed with brine (150 mL)
5. 5
   تجفيفdried over anhydrous Na2SO4
6. 6
   تركيزconcentrated in vacuo

الإجراء التجريبي

A mixture of tert-butyl (2-fluoro-5-morpholinophenyl)carbamate (0.93 g, 3.14 mmol) and a solution of HCl (31 mL, 31 mmol, 1 M in MeOH) was stirred at rt overnight, then concentrated in vacuo. The residue was dissolved in water (150 mL). The soltution was basified with saturated Na2CO3 aqueous solution and extracted with CH2Cl2 (100 mL×3). The combined organic phases were washed with brine (150 mL), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a light brown solid (0.35 g, 57%).

المصدر