تفاعل #8440

معادلة التفاعل

potassium carbonate

2-bromopropionic acid ethyl ester

product

bis-α-naphthyl-(2,4-dihydroxyphenyl)-triazine

→

Bis-α-naphthyl-(4-[1-ethoxycarbonyl-ethoxy]-2-hydroxy-phenyl)-triazine

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solid which precipitates
2. 2
   ترشيحis filtered off
3. 3
   غسيلwashed with toluene
4. 4
   أخرىChromatography of the residue on silica gel yields the product of melting point: 124–125° C.

الإجراء التجريبي

9.39 g of potassium carbonate and 9.02 g of 2-bromopropionic acid ethyl ester are added to a solution of 20.0 g of the product from Example A6 in 200 ml of DMF. The reaction mixture is heated at 125° C. for 3.5 h. The solid which precipitates is filtered off and washed with toluene. The combined organic phase is freed of solvent in vac. Chromatography of the residue on silica gel yields the product of melting point: 124–125° C.

المصدر