تفاعل #84341

معادلة التفاعل

2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone

methoxyamine hydrochloride

→

desired product

المردود 84.9%

2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone-O-methyloxime

المردود 84.9%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction
2. 2
   أخرىthe solvent was evaporated under reduced pressure
3. 3
   أخرىthe resulting residue was purified by silica gel column chromatography

الإجراء التجريبي

To 1.3 g of 2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone in 10 ml of ethanol, 362 mg of methoxyamine hydrochloride was added, and the mixture was stirred at room temperature for 13 hours. After completion of the reaction, the solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 0:100 to 5:95) to obtain 1.2 g of the desired product as a colorless oil.

المصدر