تفاعل #84254

معادلة التفاعل

1-(3,5-dichloropyridin-2-yl)ethanone

trimethylphenylammonium tribromide

→

desired product

المردود 161.1%

2-bromo-1-(3,5-dichloropyridin-2-yl)ethanone

المردود 161.1%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction
2. 2
   ترشيحthe precipitated solid was filtered off through celite
3. 3
   أخرىthe solvent was evaporated under reduced pressure
4. 4
   أخرىThe resulting residue was purified by silica gel column chromatography

الإجراء التجريبي

To 5.00 g of 1-(3,5-dichloropyridin-2-yl)ethanone in 75 ml of tetrahydrofuran, 9.94 g of trimethylphenylammonium tribromide was added, and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, the precipitated solid was filtered off through celite, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 5:95 to 15:85) as the eluent to obtain 6.64 g of the desired product as a brown oil.

المصدر