تفاعل #84091

معادلة التفاعل

2-chloro-6-methoxyquinoline

5-cyanothiophen-2-ylboronic acid

sodium carbonate

→

5-(6-hydroxyquinolin-2-yl)thiophene-2-carbonitrile

المذيبات

DME

ظروف التفاعل

المعالجة

1. 1
   أخرىthe two step synthesis
2. 2
   أخرىIn step 2, after quenching w/ice water
3. 3
   استخلاصa standard ethyl acetate extraction
4. 4
   أخرىwas preformed followed by purification by prep-TLC (PE: EA=1:1)

الإجراء التجريبي

Followed the two step synthesis shown in Scheme 1 starting with 2-chloro-6-methoxyquinoline and 5-cyanothiophen-2-ylboronic acid, with minor variations: the base used in step 1 was sodium carbonate and the solvent was DME (dimethoxyethane)/water. In step 2, after quenching w/ice water, a standard ethyl acetate extraction was preformed followed by purification by prep-TLC (PE: EA=1:1).

المصدر