تفاعل #84089

معادلة التفاعل

ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate

→

desired product

المردود 26.0%

ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohexanecarboxylate

المردود 26.0%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered off
2. 2
   تركيزthe filtrate was concentrated
3. 3
   أخرىto give the crude product, which
4. 4
   أخرىwas purified by silica gel column (PE/EtOAc=10/1)

الإجراء التجريبي

To ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate (900 mg, 2.60 mmol) in EtOH (40 mL) was added Rh(PPh3)3Cl (90.0 mg 0.0900 mmol). The mixture was stirred at 30° C. for 4 days under H2 (15 psi). The mixture was filtered off and the filtrate was concentrated to give the crude product, which was purified by silica gel column (PE/EtOAc=10/1) to give the desired product (234 mg, yield 26%).

المصدر