تفاعل #84088

ord-3245a4a8894c42d9b3548bee38239b8e

معادلة التفاعل

CCOC(=O)C1CC=C(B2OC(C)(C)C(C)(C)O2)CC1
ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate
COc1ccc2nc(Cl)c(Cl)cc2c1
2,3-dichloro-6-methoxyquinoline
COc1ccc2nc(Cl)c(Cl)cc2c1
Intermediate 4
COc1ccc2nc(Cl)c(Cl)cc2c1
2,3-dichloro-6-methoxyquinoline
CCOC(=O)C1CC=C(c2nc3ccc(OC)cc3cc2Cl)CC1
ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Followed Scheme 2, Step 1 (see Ex. 8, Step 1) starting from ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate and 2,3-dichloro-6-methoxyquinoline (Intermediate 4).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09433618B2uspto-grants-2016_09