تفاعل #84069

معادلة التفاعل

4-(6-hydroxyquinolin-2-yl)benzonitrile

NH2OH.HCl

→

desired product

المردود 78.0%

N-hydroxy-4-(6-hydroxyquinolin-2-yl)benzimidamide

المردود 78.0%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   تركيزfollowed by concentration in vacuo
2. 2
   workup.STIRRINGstirred for 1 hour
3. 3
   ترشيحFiltration
4. 4
   أخرىdrying of the solids

الإجراء التجريبي

See Scheme 4, route B. 4-(6-hydroxyquinolin-2-yl)benzonitrile (900 mg, 3.68 mmol) was dissolved in 25 mL of EtOH and to it was added NH2OH.HCl (500 mg, 7.36 mmol) and TEA (1.5 mL). The mixture was stirred at 80° C. for 2 hours followed by concentration in vacuo. The crude solids were then suspended in 25 mL of H2O and stirred for 1 hour. Filtration and drying of the solids yielded desired product (800 mg, 78% yield).

المصدر