تفاعل #84066

معادلة التفاعل

4-cyanophenylboronic acid

2,4-dichloro-6-methoxyquinoline

→

desired product

4-(4-chloro-6-methoxyquinolin-2-yl)benzonitrile

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   أخرىThe resulting solid was isolated by filtration
3. 3
   غسيلwashed with water
4. 4
   أخرىdried
5. 5
   أخرىfollowed by recrystallization from methanol

الإجراء التجريبي

Followed Scheme 2, Step 1 starting from 4-cyanophenylboronic acid and 2,4-dichloro-6-methoxyquinoline, where the solvent used was DMF, and the catalyst used was Pd(PPh3)4. The mixture was heated to 100° C. for 3 h, allowed to cool, and then poured into ice water. The resulting solid was isolated by filtration, washed with water, and dried followed by recrystallization from methanol to give the desired product.

المصدر