تفاعل #84053

معادلة التفاعل

6-aminoquinoline

pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

DMF

hydrochloric acid

carbonate

→

title compound

2-(1-Azabicyclo[2.2.2]oct-3-yl)-N-(7-quinolinyl)acetamide hydrochloride

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   workup.WAITAfter 1 h
2. 2
   ترشيحthe polystyrene resin is filtered off
3. 3
   غسيلwashed with THF
4. 4
   تركيزThe combined filtrates are concentrated in vacuo
5. 5
   أخرىthe crude product is purified by preparative HPLC
6. 6
   أخرىThe hydrochloride is prepared
7. 7
   workup.ADDITIONby mixing the product
8. 8
   تركيزconcentrating again
9. 9
   أخرىDrying under high vacuum

الإجراء التجريبي

90.3 mg (0.24 mmol) of pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride are dissolved in 1 ml of DMF, mixed with 51.6 mg (0.36 mmol) of 6-aminoquinoline and stirred at room temperature overnight. 1 g of MP-carbonate (polymer-bound carbonate, capacity: 2.5-3.5 mmol/g; from Argonaut Technologies, USA) is added. After 1 h, the polystyrene resin is filtered off and washed with THF. The combined filtrates are concentrated in vacuo, and the crude product is purified by preparative HPLC. The hydrochloride is prepared by mixing the product with a mixture of 1 M hydrochloric acid and acetonitrile and concentrating again. Drying under high vacuum results in 44 mg (50.2% of theory) of the title compound.

المصدر