تفاعل #84050

معادلة التفاعل

pentafluorophenol

EDC

1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride

→

Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   تركيزThe contents of the flask are concentrated in vacuo
2. 2
   أخرىdried under high vacuum
3. 3
   أخرىThe resulting crude product is employed without further purification in the following stages

الإجراء التجريبي

358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.

المصدر