تفاعل #84049

معادلة التفاعل

methyl 6-bromo-1-benzothiophene-2-carboxylate

potassium hydroxide

→

desired product

6-Bromo-1-benzothiophene-2-carboxylic acid

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent is removed in vacuo
2. 2
   ترشيحThe resulting precipitate is filtered off with suction
3. 3
   غسيلwashed with water
4. 4
   أخرىdried in vacuo at 50° C

الإجراء التجريبي

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.

المصدر