تفاعل #84048

معادلة التفاعل

quinuclidin-3-one hydrochloride

sodium methoxide

→

title compound

Quinuclidin-3-one

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe resulting precipitate is filtered off with suction
2. 2
   تركيزthe filtrate is concentrated in vacuo
3. 3
   أخرىThe residue is partitioned between chloroform and water
4. 4
   استخلاصextracted with chloroform
5. 5
   تجفيفThe combined organic phases are dried over sodium sulfate
6. 6
   تركيزconcentrated in vacuo

الإجراء التجريبي

100 g (0.62 mol) of quinuclidin-3-one hydrochloride are suspended in 2 l of methanol. At 0° C., a solution of 33.4 g (0.62 mol) of sodium methoxide in 250 ml of methanol is slowly added dropwise. The mixture is stirred at room temperature for 16 h. The resulting precipitate is filtered off with suction, and the filtrate is concentrated in vacuo. The residue is partitioned between chloroform and water and extracted with chloroform. The combined organic phases are dried over sodium sulfate and concentrated in vacuo. 58.8 g (75.9% of theory) of the title compound are obtained.

المصدر