تفاعل #838026

ord-72ef9bbfc72c40138aae1db19af93817

معادلة التفاعل

CS(=O)(=O)c1ncc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1
2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine
Oc1cccc(Cl)c1
3-chlorophenol
Clc1ccc(-c2cnc(Oc3cccc(Cl)c3)nc2-c2ccc(Cl)cc2Cl)cc1
2-(3-chlorophenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine from Reference Example 3 was reacted with 3-chlorophenol according to the procedure described in Example 74 to afford 2-(3-chlorophenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine: HPLC/MS: m/e=461 (M++1); Rt=4.72 min; 1H-NMR 400 MHz (CDCl3): δ 7.00-7.12. (m, 2H), 7.11-7.18 (m, 2H), 7.20-7.30 (m, 7H), 8.60 (s, 1H).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07405221B2uspto-grants-2008_07