تفاعل #838025

ord-28afb0489366482e9c6b56b1facd0f6b

معادلة التفاعل

CS(=O)(=O)c1ncc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1
2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine
Oc1ccc(F)c(F)c1
3,4-difluorophenol
Fc1ccc(Oc2ncc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)n2)cc1F
2-(3,4-difluorophenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine from Reference Example 3 was reacted with 3,4-difluorophenol according to the procedure described in Example 74 to afford 2-(3,4-difluorophenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine: HPLC/MS: m/e=463 (M++1); Rt=4.60 min; 1H-NMR 400 MHz (CDCl3): δ 7.05. (m, 3H), 7.19-7.30 (m, 6H), 7.39 (d, J=2 Hz, 1H), 8.60 (s, 1H).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07405221B2uspto-grants-2008_07