تفاعل #838024

ord-b13c7d48891648e9a4be92d9512b179c

معادلة التفاعل

CS(=O)(=O)c1ncc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2Cl)n1
2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine
Oc1cccc(F)c1
3-fluorophenol
Fc1cccc(Oc2ncc(-c3ccc(Cl)cc3)c(-c3ccc(Cl)cc3Cl)n2)c1
2-(3-fluorophenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

2-Methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine from Reference Example 3 was reacted with 3-fluorophenol according to the procedure described in Example 74 to afford 2-(3-fluorophenyloxy)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine: HPLC/MS: m/e=445 (M++1); Rt=4.50 min; 1H-NMR 400 MHz (CDCl3): δ 7.05. (m, 3H), 7.21-7.30 (m, 6H), 7.38-7.42 (m, 2H), 8.60 (s, 1H).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07405221B2uspto-grants-2008_07