تفاعل #837983

معادلة التفاعل

DMF

2-methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

dimethylamine

→

2-(N,N-Dimethylamino)-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONTo a 25 mL thick glass wall pressure tube was added a stirrer bar
2. 2
   أخرىthe tube sealed
3. 3
   أخرىThe solvents were removed under high vacuum
4. 4
   أخرىproduct was obtained

الإجراء التجريبي

To a 25 mL thick glass wall pressure tube was added a stirrer bar, 4 mL DMF and 2-methylsulfonyl-4-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyrimidine (42 mg 0.1 mmol). Then excess dimethylamine in ether (2M) was added, the tube sealed and heated at 100° C. for 18 h. The solvents were removed under high vacuum, and product was obtained. HPLC/MS: m/e=379 (M+1); Rt=3.79 min; 1H-NMR 500 MHz (CDCl3): δ 3.18 (s, 6H), 7.40 (d, J=9 Hz, 1H), 7.5-7.6 (m, 3H), 7.8 (m, 2H), 8.20 (s, 1H).

المصدر