تفاعل #83740

معادلة التفاعل

2(S)-amino-3(S)-carboxy-4(R)-pentanolide

sodium hydroxide

→

2(S)-amino-3(S)-carboxy-4(R)-hydroxypentanoic acid

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONThe solvent mixture is distilled off
2. 2
   workup.ADDITIONacetonitrile is added to the oily residue
3. 3
   ترشيحThe crystals which gradually form are filtered off
4. 4
   غسيلwashed with a small amount of acetonitrile
5. 5
   أخرىdried under a high vacuum
6. 6
   أخرى[α]D20 =-9.0° (1% in water)

الإجراء التجريبي

2.07 g of 2(S)-amino-3(S)-carboxy-4(R)-pentanolide are suspended in 10 ml of methanol and dissolved by the addition of 13 ml of 2N aqueous sodium hydroxide solution with stirring at room temperature. The solvent mixture is distilled off and acetonitrile is added to the oily residue. The crystals which gradually form are filtered off, washed with a small amount of acetonitrile and dried under a high vacuum. The disodium salt of the title compound remains behind, [α]D20 =-9.0° (1% in water). 1H-NMR (D2O): 1.21 (3H, d 6.4 Hz), 2.54 (1H, dxd 6.4 and 8.4 Hz), 3.49 (1H, d 6 Hz), 3.97 (1H, dxq 8.4 and 6.4 Hz).

المصدر