تفاعل #83683

معادلة التفاعل

(3aRS,7aRS)-2-benzyl-7,7-dimethyl-4-perhydroisoindolone

hydrochloric acid

→

(3aRS,7aRS)-7,7-dimethyl-4-perhydroisoindolone hydrochloride

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGhydrogenated, with stirring, at a temperature of 60° C. and at atmospheric pressure
2. 2
   أخرىAfter reaction for 6 hours
3. 3
   ترشيحthe reaction mixture is filtered
4. 4
   تركيزconcentrated to dryness under reduced pressure (2.7 kPa)

الإجراء التجريبي

A mixture of 2.31 g of (3aRS,7aRS)-2-benzyl-7,7-dimethyl-4-perhydroisoindolone and 9.96 cm3 of 1N hydrochloric acid in 25 cm3 of anhydrous ethanol is heated to 60° C. with stirring; 0.11 g of 20% palladium hydroxide on charcoal is added and the reaction mixture is then hydrogenated, with stirring, at a temperature of 60° C. and at atmospheric pressure. After reaction for 6 hours, the reaction mixture is filtered and then concentrated to dryness under reduced pressure (2.7 kPa). 2.17 g of (3aRS,7aRS)-7,7-dimethyl-4-perhydroisoindolone hydrochloride are obtained, in the form of a pink oil containing ethanol.

المصدر