تفاعل #83630

معادلة التفاعل

(2aS,4R)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

potassium hydroxide

→

debenzoylated product

المردود 96.7%

(2aS,4R)-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

المردود 96.7%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed under nitrogen for 5 hours
2. 2
   استخلاصthe product was extracted into methylene chloride
3. 3
   أخرىAfter drying the
4. 4
   استخلاصextract over sodium sulfate the solvent
5. 5
   أخرىwas evaporated

الإجراء التجريبي

A mixture of 100 g (0.21 mol) of (2aS,4R)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole and 1 liter of 1M ethanolic potassium hydroxide was refluxed under nitrogen for 5 hours. The cooled mixture was diluted with two volumes of water, and the product was extracted into methylene chloride. After drying the extract over sodium sulfate the solvent was evaporated leaving 78 g of the debenzoylated product as a light brown oil.

المصدر