تفاعل #83593

معادلة التفاعل

3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester

3-ethinylbenzoic acid methyl ester

→

3-{3-hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester

المردود 46.2%

ظروف التفاعل

المعالجة

1. 1
   أخرىthe crude product is chromatographed on silica gel with hexane/0-20% ethyl acetate

الإجراء التجريبي

Under the conditions of example 5A, 9.2 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 4.8 g of 3-ethinylbenzoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-20% ethyl acetate. 4.7 g of 3-{3-hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester of melting point 125°-127° C. is obtained.

المصدر