تفاعل #83588

معادلة التفاعل

3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester

4-pentynoic acid methyl ester

→

5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester

المردود 84.3%

ظروف التفاعل

المعالجة

1. 1
   أخرىthe crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate

الإجراء التجريبي

Under the conditions of example 5A, 2 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 0.8 g of 4-pentynoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate. 1.6 g of 5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester of melting point 119°-121° C. is obtained.

المصدر