تفاعل #83581

معادلة التفاعل

N-benzenesulfonyl-4-ethinylbenzoic acid amide

3-{6-iodo-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester

→

3-{3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-6-[2-(4-benzenesulfonamidocarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester

المردود 30.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىthe crude product is chromatographed on silica gel with dichloromethane/0-5% methanol

الإجراء التجريبي

Under the conditions of example 5 A, 1.31 g of the crude N-benzenesulfonyl-4-ethinylbenzoic acid amide is reacted with 1.9 g of 3-{6-iodo-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with dichloromethane/0-5% methanol. 750 mg of 3-{3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-6-[2-(4-benzenesulfonamidocarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester is obtained as oil.

المصدر