تفاعل #83576

معادلة التفاعل

4-ethinylphenylacetic acid methyl ester

3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester

→

3-{3-hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester

المردود 39.6%

ظروف التفاعل

المعالجة

1. 1
   أخرىthe crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate

الإجراء التجريبي

Under the conditions of example 5 A, 5 g of the crude 4-ethinylphenylacetic acid methyl ester is reacted with 7.9 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate. 3.6 g of 3-{3-hydroxy-6-[2-(4-methoxycarbonylmethylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester of melting point 122°-125° C. is obtained.

المصدر