تفاعل #83541

معادلة التفاعل

3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester

(1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene

→

3-{6-iodo-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester

المردود 68.6%

ظروف التفاعل

المعالجة

1. 1
   أخرىthe crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate

الإجراء التجريبي

Under the conditions of example 1 D, 850 mg of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 612 mg of (1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene, worked up, and the crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate. 773 mg of 3-{6-iodo-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester is obtained as colorless oil.

المصدر