تفاعل #83346

معادلة التفاعل

2-Chloro-6-methoxyquinoline

4-aminothiophenol

dimethylaminopyridine

→

2-(4-aminophenylthio)-6-methoxyquinoline

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىcondensed
2. 2
   أخرىpurified by HPLC over silica gel
3. 3
   غسيلeluted with 25-30% ethyl acetate/hexane

الإجراء التجريبي

2-Chloro-6-methoxyquinoline (52.0 mmoles, 10.0 g), 4-aminothiophenol (52.0 mmoles, 6.5 g) and dimethylaminopyridine (52.0 mmoles, 6.3 g) were stirred for 16 hr in 250 ml ethanol. The reaction was condensed and purified by HPLC over silica gel eluted with 25-30% ethyl acetate/hexane to yield 2-(4-aminophenylthio)-6-methoxyquinoline. 8.5 g, 58% product. Mass spec (FD) 282. Calculated for C16H14N2OS: C, 68.06; H, 5.00, N, 9.92. Found: C, 68.04; H, 4.97; N, 10.02.

المصدر