تفاعل #83254

معادلة التفاعل

HCl

4,5-dimethoxyphthalic anhydride

phenylmagnesium chloride

ammonium chloride

→

2-benzoyl-4,5-dimethoxybenzoic acid

المردود 74.9%

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for two hours
2. 2
   درجة الحرارةcooled
3. 3
   استخلاصextracted into chloroform
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   تركيزconcentrated

الإجراء التجريبي

Thirty grams (0.14 mole) of 4,5-dimethoxyphthalic anhydride was suspended in 300 mL of THF and 87 mL (0.17 mole) of phenylmagnesium chloride in THF was added over two hours. The reaction was stirred at room temperature for 14 hours, refluxed for two hours, cooled and poured into saturated ammonium chloride. The mixture was made acidic with 6N HCl, extracted into chloroform, dried over magnesium sulfate, concentrated to provide 30 g of 2-benzoyl-4,5-dimethoxybenzoic acid.

المصدر