تفاعل #83213

معادلة التفاعل

water

4-fluorophenylacetonitrile

ethyl isonicotinate

Sodium

→

2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe solution was refluxed for 3 hours
2. 2
   درجة الحرارةThe reaction mixture was cooled
3. 3
   أخرىThe ethanol of the mixture was removed under reduced pressure
4. 4
   غسيلThe resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid
5. 5
   أخرىThe separated solid was collected
6. 6
   غسيلwashed with water
7. 7
   أخرىdried

الإجراء التجريبي

Sodium (2.48 g) was dissolved in dry ethanol (37 ml) under nitrogen atmosphere. To the solution was added 4-fluorophenylacetonitrile (11.65 g) and ethyl isonicotinate (16.41 ml) and the solution was refluxed for 3 hours. The reaction mixture was cooled and poured into water. The ethanol of the mixture was removed under reduced pressure. The resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid. The separated solid was collected, washed with water and dried to give 2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile (16.43 g).

المصدر