تفاعل #83182

معادلة التفاعل

alpha-(4-chlorophenyl)-alpha-ethyl-1H-1,2,4-triazole-1-propanenitrile

sodium hydroxide

→

white solid

المردود 91.6%

2-(4-chlorophenyl)-2-[(1,2,4-triazol-1-yl)methyl]butyramide

المردود 91.6%

المذيبات

dimethyl sulfoxide

ظروف التفاعل

المعالجة

1. 1
   أخرىwas consumed
2. 2
   workup.ADDITIONThe reaction was poured into water
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلAfter washing with brine
5. 5
   تجفيفthe organic phase was dried over magnesium sulfate
6. 6
   تركيزconcentrated under vacuum
7. 7
   درجة الحرارةwithout heating
8. 8
   أخرىRemoval of the solvent
9. 9
   أخرىgave a foamy glassy solid which
10. 10
    أخرىwas triturated with hexane
11. 11
    ترشيحfiltered

الإجراء التجريبي

To a 500 mL flask was charged 100.0 g (0.38 mole) of alpha-(4-chlorophenyl)-alpha-ethyl-1H-1,2,4-triazole-1-propanenitrile and 100 mL of dimethyl sulfoxide. To the stirring solution was added 100 g (1.25 mole) of 50% sodium hydroxide. The reaction mixture was heated at 100° C. for 1 hour after which GLC indicated the starting material was consumed. The reaction was poured into water and extracted with ethyl acetate. After washing with brine, the organic phase was dried over magnesium sulfate and concentrated under vacuum without heating. Removal of the solvent gave a foamy glassy solid which was triturated with hexane, filtered and gave 97 g (91% yield) of a white solid, melting point 139°-140° C.

المصدر