تفاعل #83103

معادلة التفاعل

product

1,4-Anhydro-2-S-[(4-methoxyphenyl)methyl]-2-thio-L-arabinitol 5-(4-Methylbenzenesulfonate)

lithium azide

→

desired product

المردود 32.6%

1,4-Anhydro-5-azido-5-deoxy-2-S-[(4-methoxyphenyl)methyl]-2-thio-L-arabinitol

المردود 32.6%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture is concentrated in vacuo
2. 2
   أخرىThe residue is purified by chromatography (Silica gel: 30% ethyl acetate/hexane)

الإجراء التجريبي

A mixture of 2.0 g of product from Example 324, 0.460 g of lithium azide and 2 ml of N,N-dimethylformamide is stirred at 70° C. for 65 hours. The reaction mixture is concentrated in vacuo. The residue is purified by chromatography (Silica gel: 30% ethyl acetate/hexane) to give 0.454 g of the desired product.

المصدر