تفاعل #83102

معادلة التفاعل

product

1,4-Anhydro-2-S-[(4-methoxyphenyl)methyl]-2-thio-L-arabinitol

p-toluenesulfonyl chloride

→

desired product

المردود 57.1%

1,4-Anhydro-2-S-[(4-methoxyphenyl)methyl]-2-thio-L-arabinitol 5-(4-Methylbenzenesulfonate)

المردود 57.1%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture is quenched with water
2. 2
   استخلاصextracted with diethyl ether
3. 3
   غسيلwashed with water and saturated sodium chloride
4. 4
   أخرىdried
5. 5
   تركيزconcentrated in vacuo
6. 6
   أخرىThe residue is purified by chromatography (Silica gel: 50% ethyl acetate/hexane)

الإجراء التجريبي

To a 0° C. solution, under argon, of 0.580 g of product from Example 323 in 10 ml of pyridine is added 0.430 g of p-toluenesulfonyl chloride. The reaction is stirred at room temperature overnight. The mixture is quenched with water, extracted with diethyl ether, washed with water and saturated sodium chloride, dried and concentrated in vacuo. The residue is purified by chromatography (Silica gel: 50% ethyl acetate/hexane) to give 0.520 g of the desired product.

المصدر