تفاعل #83095

ord-1849cdd34ca7460f86457d497ba7c0d0

معادلة التفاعل

O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
product
O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester
CC[C@H](C)[C@H](N)C(=O)O
L-isoleucine
CCN(CC)CC
triethylamine
CCO
ethyl alcohol
→
CC[C@H](C)[C@H](NC(=O)OCc1ccc([N+](=O)[O-])cc1)C(=O)O
desired product
المردود 24.5%
CC[C@H](C)[C@H](NC(=O)OCc1ccc([N+](=O)[O-])cc1)C(=O)O
N-[[(4-Nitrophenyl)methoxy]carbonyl]-L-isoleucine
المردود 24.5%

المتفاعلات

O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
product
O=C(OCc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](=O)[O-])cc1
Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester
CC[C@H](C)[C@H](N)C(=O)O
L-isoleucine
CCN(CC)CC
triethylamine
CCO
ethyl alcohol

الكواشف

لا شيء

المذيبات

O
water

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound is prepared by the procedure of Example 255 using 14.73 g of product from Example 254, 6.07 g of L-isoleucine, 12.73 ml of triethylamine and 556 ml of 4:1 ethyl alcohol:water to give 3.52 g of the desired product.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05623081uspto-grants-1997_04