تفاعل #83064

معادلة التفاعل

product

Ethanethioic acid S-[tetrahydro-5-(iodomethyl)-3-thienyl]ester

tetra-n-butyl-ammonium azide

→

desired product

المردود 46.4%

Ethanethioic acid S-[5-(azidomethyl)tetrahydro-3-thienyl]ester

المردود 46.4%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction is concentrated in vacuo
2. 2
   أخرىthe residue purified by chromatography (silica gel: 0-10% diethyl ether/hexane)

الإجراء التجريبي

A solution, under argon, of 0.183 g of product from Example 140 in 1.0 ml of dry methylene chloride is treated with 0.689 g of tetra-n-butyl-ammonium azide. The reaction mixture is stirred vigorously overnight at room temperature. The reaction is concentrated in vacuo and the residue purified by chromatography (silica gel: 0-10% diethyl ether/hexane) to give 0.061 g of the desired product.

المصدر