تفاعل #83048

ord-e9fde5dbddf24aa187440e8f06f25743

معادلة التفاعل

O=S(=O)(C[C@H]1C[C@@H](Br)CO1)c1ccc(F)cc1
product
O=S(=O)(C[C@H]1C[C@@H](Br)CO1)c1ccc(F)cc1
cis-(+/-)-4-Bromo-2-[[(4-fluorophenyl)sulfonyl]methyl]tetrahydrofuran
CC([O-])=S.[K+]
potassium thioacetate
→
CC(=O)S[C@@H]1CO[C@@H](CS(=O)(=O)c2ccc(F)cc2)C1
desired product
المردود 55.8%
CC(=O)S[C@@H]1CO[C@@H](CS(=O)(=O)c2ccc(F)cc2)C1
Ethanethioic acid trans-(+/-)-S-[5-[[(4-fluorophenyl)sulfonyl]methyl]tetrahydro-3-furanyl]ester
المردود 55.8%

المتفاعلات

O=S(=O)(C[C@H]1C[C@@H](Br)CO1)c1ccc(F)cc1
product
O=S(=O)(C[C@H]1C[C@@H](Br)CO1)c1ccc(F)cc1
cis-(+/-)-4-Bromo-2-[[(4-fluorophenyl)sulfonyl]methyl]tetrahydrofuran
CC([O-])=S.[K+]
potassium thioacetate

الكواشف

لا شيء

المذيبات

CC#N
acetonitrile

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound is prepared by the procedure of Example 5 using 0.969 g of product from Example 30, 0.360 g of potassium thioacetate, and 9 ml of acetonitrile to give 0.533 g of the desired product.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05623081uspto-grants-1997_04