تفاعل #8301

معادلة التفاعل

1-fluoronaphthalene

paraformaldehyde

phosphoric acid

hydrochloric acid

acetic acid

→

title compound

1-Chloromethyl-4-fluoronaphthalene

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted three times with dichloromethane
2. 2
   غسيلwashed with water and brine
3. 3
   تجفيفdried (sodium sulfate)
4. 4
   ترشيحfiltered
5. 5
   أخرىevaporated

الإجراء التجريبي

A solution of 1-fluoronaphthalene (5.5 g, 37.6 mmol), paraformaldehyde (2.5 g, 83 mmol), glacial acetic acid (3.5 mL), phosphoric acid (2 mL) and concentrated hydrochloric acid (5 mL) is heated at 85° C. for 15 h. The reaction mixture is poured into water and extracted three times with dichloromethane. The organic extracts are combined and washed with water and brine, dried (sodium sulfate), filtered, and evaporated to yield the title compound, 6.53 g (98%, as a yellow solid.

المصدر