تفاعل #8293

معادلة التفاعل

4-acetoxy-3-phenyl-butyric acid methyl ester

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title compound

4-Phenyl-dihydro-furan-2-one

المذيبات

1,4-dioxane

sulfuric acid

ظروف التفاعل

المعالجة

1. 1
   أخرىVolatile solvents are evaporated
2. 2
   استخلاصthe residue is extracted with toluene
3. 3
   استخلاصThe combined organic extracts are extracted with water and brine
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated

الإجراء التجريبي

A solution of 4-acetoxy-3-phenyl-butyric acid methyl ester, (4.5 g, 19.2 mmol) in 1,4-dioxane (29 mL) and sulfuric acid (29 mL) is stirred at room temperature for one hour then heated at 45° C. for 18 h. Volatile solvents are evaporated and the residue is extracted with toluene. The combined organic extracts are extracted with water and brine, filtered, and concentrated to yield the title compound, 2.2 g (71%), as a colorless liquid.

المصدر