تفاعل #82447

معادلة التفاعل

lithium hydroxide

ethyl trans-4-methyl-2,4-pentadienecarboxylate

→

trans-4-methyl-2,4-pentadienecarboxylic acid

المردود 76.0%

المذيبات

water

methanol

tetrahydrofuran

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصis extracted once using diethyl ether
2. 2
   أخرىis established in the aqueous phase at 0° C.
3. 3
   استخلاصThe mixture is extracted
4. 4
   غسيلthe combined organic phases are washed several times with water and saturated sodium chloride solution
5. 5
   أخرىafter drying
6. 6
   تركيزconcentrating

الإجراء التجريبي

2.5 g (0.1 mol) of lithium hydroxide are added at 0° C. to 10 g (0.07 mol) of ethyl trans-4-methyl-2,4-pentadienecarboxylate, dissolved in a solvent mixture of 75 ml of methanol, 17 ml of tetrahydrofuran and 2.5 ml of water, and the mixture is stirred for 20 hours at room temperature. After the mixture has been diluted with 200 ml of water, it is extracted once using diethyl ether, and a pH of 1 is established in the aqueous phase at 0° C. using concentrated hydrochloric acid. The mixture is extracted using diethyl ether, the combined organic phases are washed several times with water and saturated sodium chloride solution, and, after drying and concentrating, 6.1 g (76% of theory) of trans-4-methyl-2,4-pentadienecarboxylic acid are obtained. ##STR208##

المصدر