تفاعل #82331

معادلة التفاعل

[N-(benzyloxycarbonyl)-L-phenylalanyl]methyl bromide

N2 L-prolyl-N1 -isobutyl-L-isoleucinamide

triethylamine

→

N2 [N-[[N-(benzyloxycarbonyl)-L-phenylalanyl]methyl]-L-prolyl]-N1 -isobutyl-L-isoleucinamide

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed by evaporation
2. 2
   أخرىthe crude product was chromatographed on silica gel
3. 3
   غسيلfor the elution
4. 4
   أخرىThe resulting product was triturated with a mixture of petroleum ether (b.p. 40°-60° C.) and ethyl acetate

الإجراء التجريبي

A solution of 8.86 g of [N-(benzyloxycarbonyl)-L-phenylalanyl]methyl bromide 6.71 g of N2 -L-prolyl-N1 -isobutyl-L-isoleucinamide and 2.60 g of triethylamine in 400 ml of dichloromethane was stirred at room temperature overnight. The solvent was removed by evaporation and the crude product was chromatographed on silica gel using ethyl acetate for the elution. The resulting product was triturated with a mixture of petroleum ether (b.p. 40°-60° C.) and ethyl acetate to give 8.70 g of N2 -[N-[[N-(benzyloxycarbonyl)-L-phenylalanyl]methyl]-L-prolyl]-N1 -isobutyl-L-isoleucinamide as an off-white solid of m.p. 80°-81° C.

المصدر