تفاعل #8232

معادلة التفاعل

methyl 4-({(5-methoxy-5-oxopentyl)[2-({4-[(E)-2-phenyl-ethenyl]benzyl}oxy)phenethyl]amino)methyl)benzoate

hydrogen

→

Methyl 4-[((5-methoxy-5-oxopentyl){2-{(4-phenethylbenzyl)oxy]-phenethyl}amino)methyl]benzoate

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solution is filtered
2. 2
   workup.DISTILLATIONthe solvent distilled off under reduced pressure
3. 3
   أخرىThe crude product is purified by chromatography over silica gel using the mobile phase cyclohexane/ethyl acetate=10:1

الإجراء التجريبي

781.8 mg (1.34 mmol) of methyl 4-({(5-methoxy-5-oxopentyl)[2-({4-[(E)-2-phenyl-ethenyl]benzyl}oxy)phenethyl]amino)methyl)benzoate from Ex. 6 and 80.0 mg of 10% palladium on activated carbon in 10 ml of ethyl acetate are hydrogenated under atmospheric pressure. After 1 hour, the calculated amount of hydrogen has been taken up. The solution is filtered and the solvent distilled off under reduced pressure. The crude product is purified by chromatography over silica gel using the mobile phase cyclohexane/ethyl acetate=10:1.

المصدر