تفاعل #82268

معادلة التفاعل

potassium hydroxide

hydrazine dihydrate

5-bromo-2-(4-methoxybenzoyl)benzofuran

→

5-bromo-2-(4-methoxybenzyl)benzofuran

المردود 82.5%

المذيبات

diethylene glycol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe thus prepared mixture was refluxed
2. 2
   درجة الحرارةunder heating
3. 3
   درجة الحرارةAfter cooling
4. 4
   أخرىthe resulting reaction solution
5. 5
   استخلاصextracted with benzene
6. 6
   أخرىdried
7. 7
   workup.DISTILLATIONAfter distilling off the solvent
8. 8
   أخرىthe resulting residue was purified

الإجراء التجريبي

5.07 g of potassium hydroxide was added to 30 ml of diethylene glycol, and the mixture was stirred at room temperature during which 5.5 g of 80% hydrazine dihydrate.2H2O and 5.0 g of 5-bromo-2-(4-methoxybenzoyl)benzofuran were further added. The thus prepared mixture was refluxed under heating. After cooling, the resulting reaction solution was adjusted to pH 4-5, extracted with benzene, and then dried. After distilling off the solvent, the resulting residue was purified by subjecting it to silica gel column chromatography using a n-hexane/isopropanol mixture as an elution solvent, thereby obtaining 3.95 g of 5-bromo-2-(4-methoxybenzyl)benzofuran as a brown oily material.

المصدر