تفاعل #82263

معادلة التفاعل

3,4-diaminobenzonitrile

ethyl chloroacetoimidate hydrochloride

→

2-chloromethyl-5-benzimidazolecarbonitrile

المردود 54.9%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe solution was refluxed
2. 2
   درجة الحرارةunder heating for 3 hours
3. 3
   درجة الحرارةAfter cooling
4. 4
   workup.DISTILLATIONdistilling off the solvent
5. 5
   workup.DISSOLUTIONthe resulting residue was dissolved in ethyl acetate
6. 6
   غسيلwashed with water
7. 7
   أخرىdried
8. 8
   workup.DISTILLATIONAfter distilling off the solvent
9. 9
   أخرىthe crystals thus precipitated
10. 10
    ترشيحwere collected by filtration

الإجراء التجريبي

3.42 g of 3,4-diaminobenzonitrile and 4.06 g of ethyl chloroacetoimidate hydrochloride were dissolved in 100 ml of ethanol, and the solution was refluxed under heating for 3 hours. After cooling and distilling off the solvent, the resulting residue was dissolved in ethyl acetate, washed with water, and then dried. After distilling off the solvent, the crystals thus precipitated were collected by filtration to obtain 2.7 g of 2-chloromethyl-5-benzimidazolecarbonitrile.

المصدر