تفاعل #82151

معادلة التفاعل

acyl azide

2-(4'-ethylenedioxy-1'-methyl-2'-oxocyclohexyl)-phenylacetyl azide

dimethylformamide

acetic acid

→

2-(2', 4'-dioxo-1'-methyl-cyclohexyl)-benzyl amine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution is cooled

الإجراء التجريبي

The acyl azide 5 is dissolved in dimethylformamide and heated to 100° C. until nitrogen evolution ceases. The solution is cooled and treated with aqueous acetic acid to form 2-(2', 4'-dioxo-1'-methyl-cyclohexyl)-benzyl amine 6. Diethyl ether is added and the solution is washed successively with saturated sodium bicarbonate solution, water, and saturated salt solution and dried over anhydrous sodium sulfate. The solvent is removed by rotoevaporation to yield 1,2,3,4,4a,5,6,10b-octahydro- 10b-methyl-3-phenanthridinone 7.

المصدر