تفاعل #8198

معادلة التفاعل

3-Methylbenzo[b]thiophene

n-bromosuccinimide

2,2′Azobisisobutyronitrile

→

3-Bromomethylbenzo[b]thiophene

المردود 42.2%

المذيبات

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe resulting mixture is refluxed for two hours
2. 2
   درجة الحرارةAfter cooling
3. 3
   ترشيحthe reaction mixture is filtered through a glass-fritted funnel
4. 4
   تركيزthe filtrate is concentrated
5. 5
   أخرىThe residue is triturated with petroleum ether and toluene

الإجراء التجريبي

3-Methylbenzo[b]thiophene (9.9 g, 67 mmol) is heated in carbon tetrachloride (133 ml ) to near reflux in the presence of n-bromosuccinimide (11.9 g, 67 mmol, 1.0 eq.). 2,2′Azobisisobutyronitrile (2.2 g, 13.3 mmol, 0.2 eq.) is added and the resulting mixture is refluxed for two hours. After cooling, the reaction mixture is filtered through a glass-fritted funnel, and the filtrate is concentrated. The residue is triturated with petroleum ether and toluene to afford 6.42 g of 3-Bromomethylbenzo[b]thiophene (42%).

المصدر