تفاعل #819657

معادلة التفاعل

5-(methyl-propylcarbamoyl)-isophthalic acid diethyl ester

NaOH

HCl

→

title compound

المردود 75.8%

5-(Methyl-propylcarbamoyl)-isophthalic acid monoethyl ester

المردود 75.8%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصextract with ethyl acetate (2×50 mL)
2. 2
   تجفيفDry (magnesium sulfate)
3. 3
   تركيزconcentrate
4. 4
   أخرىpurify (silica gel chromatography
5. 5
   غسيلeluting with 50:50 ethyl acetate

الإجراء التجريبي

Stir a solution of 5-(methyl-propylcarbamoyl)-isophthalic acid diethyl ester (2.02 g, 6.3 mmol), NaOH (0.25 g, 6.3 mmol) and ethanol (32 mL) at room temperature overnight. Add 0.2 N HCl (60 mL) and extract with ethyl acetate (2×50 mL). Dry (magnesium sulfate), concentrate and purify (silica gel chromatography, eluting with 50:50 ethyl acetate:hexanes with 1% acetic acid then 100% ethyl acetate with 1% acetic acid) to give the title compound as an oil (1.4 g, 75%).

المصدر