تفاعل #818319

معادلة التفاعل

(3-cyanomethyl-2-phenyl-imidazolidin-1-yl)-acetonitrile

2-[3-(2-Amino-ethyl)-2-phenyl-imidazolidin-1-yl]-ethylamine

intermediate ( 8 )

2-[3-(2-Amino-ethyl)-2-phenyl-imidazolidin-1-yl]-ethylamine

→

triethylenetetramine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONis treated with an acid

الإجراء التجريبي

This Example demonstrates the reduction of (3-cyanomethyl-2-phenyl-imidazolidin-1-yl)-acetonitrile (5) to intermediate 2-[3-(2-Amino-ethyl)-2-phenyl-imidazolidin-1-yl]-ethylamine (8). As shown in Scheme 9, intermediate (8) is treated with an acid to form a triethylenetetramine salt. The reduction is effected by LiAlH4, the acid used is hydrochloric acid and the tetrahydrochloride salt of triethylenetetramine is produced.

المصدر