تفاعل #81820

معادلة التفاعل

5-bromo-2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine

sodium carbonate

→

title compound

5-Bromo-2-chloro-6-(N,N-dimethylamino)-4-methylpyridine-3-carboxamide

المذيبات

water

sulfuric acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was cooled
2. 2
   استخلاصAfter extraction
3. 3
   أخرىwith methylene chloride, evaporation of the organic phase

الإجراء التجريبي

A solution of 5-bromo-2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine (1.3 g) in concentrated sulfuric acid (3 mL) was heated at 120° C. for 10 minutes. The mixture was cooled, diluted with water (50 mL), and neutralized with saturated sodium carbonate. After extraction with methylene chloride, evaporation of the organic phase gave 1.37 g of the title compound, suitable for use in the next reaction.

المصدر