تفاعل #8182

معادلة التفاعل

hydrochloric acid

Iodomethane

hydrochloric acid

Potassium bis(trimethylsilyl)amide

4-methoxy-3-methyl-1,3-dihydro-indol-2-one

→

4-methoxy-3,3-dimethyl-1,3-dihydro-indol-2-one

المردود 58.0%

المذيبات

Methanol

toluene

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto maintain the reaction temperature between −71° C. and −66° C
2. 2
   workup.WAIT−60° C. for 30 minutes
3. 3
   أخرىto rise to −7° C
4. 4
   استخلاصThe organic layer is extracted with a saturated sodium bicarbonate solution (250 mL)
5. 5
   غسيلwashed with a saturated sodium chloride solution (200 mL)
6. 6
   تجفيفdried over magnesium sulfate
7. 7
   ترشيحfiltered
8. 8
   workup.STIRRINGThe filtrate is stirred with DARCO (25 g) for 1 hour
9. 9
   ترشيحthen filtered
10. 10
    تركيزThe filtrate is concentrated by rotary evaporation
11. 11
    درجة الحرارةThe residue is refluxed for 1 hour in tert-butyl methyl ether (300 mL)
12. 12
    workup.DISTILLATIONAfter distilling out 100 mL of solvent
13. 13
    workup.STIRRINGthe slurry is stirred for 10 hours at 24° C
14. 14
    أخرىThe solid is isolated by vacuum filtration
15. 15
    غسيلrinsing twice with cold (−40° C.) tert-butyl methyl ether
16. 16
    أخرىAfter vacuum drying for 12 hours at 50° C./5 Torr

الإجراء التجريبي

A solution of 4-methoxy-3-methyl-1,3-dihydro-indol-2-one (41.73 g, 235.5 mmol) and tetrahydrofuran (1000 mL) is cooled to −78° C. Potassium bis(trimethylsilyl)amide (989.0 mL, 494.3 mmol, 0.5 M in toluene) is added over 45 minutes so as to maintain the reaction temperature between −71° C. and −66° C. Iodomethane (36.71 g, 258.7 mmol) is added over 15 minutes between −75° C. and −70° C. The mixture is stirred at −78° C. for 1 hour then −60° C. for 30 minutes. Methanol (25 mL) is added at −60° C. Aqueous, hydrochloric acid (1N, 420 mL) is added rapidly allowing the temperature to rise to −7° C. The solution is transferred to a separatory funnel with aqueous hydrochloric acid (1N, 420 mL) and toluene (50 mL). The organic layer is extracted with a saturated sodium bicarbonate solution (250 mL), washed with a saturated sodium chloride solution (200 mL), dried over magnesium sulfate, and filtered. The filtrate is stirred with DARCO (25 g) for 1 hour then filtered. The filtrate is concentrated by rotary evaporation. The residue is refluxed for 1 hour in tert-butyl methyl ether (300 mL). After distilling out 100 mL of solvent, the slurry is stirred for 10 hours at 24° C. The solid is isolated by vacuum filtration rinsing twice with cold (−40° C.) tert-butyl methyl ether. After vacuum drying for 12 hours at 50° C./5 Torr, 23.9 g (58%) of 4-methoxy-3,3-dimethyl-1,3-dihydro-indol-2-one is obtained. mp 143–144° C. MS (ES+) m/z 192 (M++1).

المصدر